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KMID : 0356219920230010027
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Journal of the Korean Military Medical Association
1992 Volume.23 No. 1 p.27 ~ p.33
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Histopathological Studies on Rat Lung Under Pure Oxygen at High Pressure
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Abstract
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Fifty rats of 150gm were used to evaluate the pulmonary oxygen toxicity and divided into 5 experimental groups as follows:
Group I: Normal control groups
Group II: Exposed to pure oxygen under 2 atmospheric pressure for 12 hours
Group III: Exposed to pure oxygen under 2 atmospheric pressure for 6 hours
Group IV: Exposed to pure oxygen under 1 atmospheric pressure for 12 hours
Group V: Exposed to pure oxygen under 1 atmospheric pressure for 6 hours
The results obtained from the pathology and histochemical studied of the lungs of experimental animals were as follows:
1. Lung/body weight ratios were significantly increased in animal exposed to pure oxygen, especially im Group II.
2. Different pathologic findings such as pulmonary edema, congestion, pneumonia, atelectasis, emphysematous change, and widening of interalveolar space were observed.
3. In histochemical studies, the reticulin fibers in the alveoli ad the respiratory bronchioles were considerably destroyed but elastic fibers were not.
4. Generally, the severity of these findings was proportional to duration of exposure and atmospheric pressure.
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KEYWORD
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